Thiazolidinediones (TZDs)
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Overview
Oral antidiabetic medications that improve insulin sensitivity by activating peroxisome proliferator-activated receptor gamma (PPAR-gamma) in fat, muscle, and liver cells. TZDs reduce insulin resistance rather than increasing insulin secretion, making them useful in type 2 diabetes management.
How do thiazolidinediones (tzds) work?
Activate peroxisome proliferator-activated receptor gamma (PPAR-gamma) in adipose tissue, liver, and muscle, improving insulin sensitivity and reducing hepatic glucose production.
Drugs in this class
- Pioglitazone (Actos)