Serotonin Modulators
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Overview
Serotonin modulators affect serotonin signaling through multiple mechanisms. Trazodone, the most well-known drug in this class, is used for depression and insomnia.
How do serotonin modulators work?
These drugs work through a combination of serotonin reuptake inhibition and serotonin receptor antagonism (particularly 5-HT2A receptors), producing both antidepressant and sedative effects.
Drugs in this class
- Trazodone (Desyrel, Oleptro)