Oxazolidinone Antibiotics
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Overview
A class of synthetic antibiotics that inhibit bacterial protein synthesis by binding to the 23S ribosomal RNA of the 50S ribosomal subunit. Oxazolidinones are particularly valuable for treating serious infections caused by multidrug-resistant Gram-positive bacteria, including MRSA and VRE.
How do oxazolidinone antibiotics work?
Bind to the 23S ribosomal RNA of the bacterial 50S ribosomal subunit, inhibiting formation of the initiation complex and blocking protein synthesis at an early stage.
Drugs in this class
- Linezolid (Zyvox)