Long-Acting Muscarinic Antagonists (LAMAs)
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Overview
Inhaled bronchodilators that block muscarinic receptors in airway smooth muscle, providing sustained bronchodilation for 24 hours or longer. LAMAs are a cornerstone of maintenance therapy for chronic obstructive pulmonary disease (COPD) and may also be used as add-on therapy for asthma.
How do long-acting muscarinic antagonists (lamas) work?
Block muscarinic M3 receptors on airway smooth muscle, preventing acetylcholine-induced bronchoconstriction and reducing mucus secretion. Long-acting formulations provide 24-hour bronchodilation.
Drugs in this class
- Tiotropium (Spiriva, Spiriva Respimat)