Anti-Gout Agents
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Overview
Medications specifically used for the treatment and prevention of acute gout flares. Colchicine, the primary agent in this class, has been used for gout for over 2,000 years and remains a first-line option for acute gout attacks and flare prophylaxis during urate-lowering therapy initiation.
How do anti-gout agents work?
Colchicine binds to tubulin and inhibits microtubule polymerization, disrupting multiple inflammatory pathways. It prevents activation of the NLRP3 inflammasome, reduces neutrophil migration to sites of urate crystal deposition, and inhibits superoxide production by neutrophils. These anti-inflammatory effects are achieved at concentrations well below those needed to affect cell division in normal tissues.
Drugs in this class
- Colchicine (Colcrys, Mitigare, Gloperba)