Alpha-1 Adrenergic Blockers
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Overview
Selective alpha-1 adrenergic receptor antagonists used primarily for the treatment of benign prostatic hyperplasia (BPH) and associated lower urinary tract symptoms. Some agents in this class are also used for hypertension management.
How do alpha-1 adrenergic blockers work?
Alpha-1 blockers selectively antagonize alpha-1 adrenergic receptors in the prostate gland and bladder neck smooth muscle. By blocking norepinephrine-mediated contraction at these sites, they relax smooth muscle tone, reducing urethral resistance and improving urinary flow. Tamsulosin is selective for the alpha-1A subtype, which predominates in prostatic tissue, providing targeted uroselective effects.
Drugs in this class
- Tamsulosin (Flomax)